The draw for the 2021-22 TotalEnergies CAF Champions League Group Stage was conducted at CAF Headquarters in Cairo, Egypt on Tuesday 28 December 2021.

Pitso Mosimane, coach of Egyptian giants Al Ahly SC, assisted Khaled Nassar, CAF Head of Competitions in the draw that paved the way towards the group stage of the premier continental club competition.

Following are the groups:

Group A

Al Ahly (Egypt) - Mamelodi Sundowns (South Africa) - Al Hilal (Sudan) - Al Merriekh (Sudan)

Group B

Raja (Morcco) - Horoya (Guinea) - ES Setif (Algeria) - AmaZulu (South Africa)

Group C

Esperance (Tunisia) - Etoile du Sahel (Tunisia) - CR Belouizdad (Algeria) - Jwaneng Galaxy (Botswana)

Group D

Wydad (Morocco) - Zamalek (Egypt) - Petro Atletico (Angola) - GD Sagrada Esperanca (Angola)

Full Match Schedule per Group:

Group A

Group B

Group C

Group D