African giants will be banking on their home ground advantage in their CAF Champions League quarter-final second-leg encounters.
Two-time African champions Wydad Casablanca are set to welcome Algerian side CR Belouizdad at the Stade Mohammed V in Morocco on Sunday at midnight.
Wydad are leading 1-0 on aggregate courtesy of Guy Mbenza's second-half goal in the first-leg encounter which was played in Algeria on April 16.
Meanwhile, four-time African champions Esperance de Tunis will play host to ES Setif of Algeria at the Stade Hammadi Agrebi in Tunisia on Friday night.
Setif were held to a 0-0 draw by the Tunisian champions in the first-leg clash in Algeria on April 15 with Esperance dominating the game without scoring.
While Mamelodi Sundowns, who lifted the 2016 Champions League title, will be desperate for a win when they host Petro de Luanda at FNB Stadium on Saturday afternoon.
The South African champions are trailing 2-1 on aggregate having suffered a surprise defeat to Petro in the first-leg encounter in Angola on April 16.
Lastly, defending champions Al Ahly will be looking to avoid a defeat in order to progress to the semi-finals when they face Raja Casablanca of Morocco on Saturday at midnight.
The two teams will meet at the Stade Mohammed V in Morocco with Al Ahly having claimed a 2-1 win in the first-leg match in Egypt on April 16.
The winner on aggregate between Al Ahly and Raja will take on either Esperance or Setif in the semi-finals, while Sundowns or Petro will face Wydad or Belouizdad in the last four.
CAF Champions League - Quarter-finals second-leg fixtures
Friday, April 22
22h00 - Esperance de Tunis v ES Setif
Saturday, April 23
17h00 - Mamelodi Sundowns v Petro de Luanda
23h00 - Raja Casablanca v Al Ahly
Sunday, April 24
23h00 - Wydad Casablanca v CR Belouizdad